Abstract

Objective: We applied a meta-analysis to explore the effect of ulinastatin (UTI) on the serum levels of C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) in Asian patients with acute pancreatitis (AP). Methods: Various databases were searched based on stringent inclusion and exclusion criteria to extract relevant cohort studies. Comprehensive Meta-analysis 2.0 (Biostat Inc., Englewood, NJ, USA) was applied for statistical analyses. Results: A total of 113 relevant studies (67 in Chinese, 46 in English) were initially retrieved. Finally, 11 eligible studies were enrolled in our meta-analysis with 399 pancreatitis patients. Meta-analysis results showed that after being treated with UTI, the serum levels of CRP, IL-6, and TNF-α were evidently decreased (CRP: SMD = –2.697, 95% CI = –4.399 ~ –0.994, p = 0.002; IL-6: SMD = –5.268, 95% CI = –9.850 ~ –0.687, p = 0.024; TNF-α: SMD = –5.666, 95% CI = –11.083 ~ –0.249, p = 0.040). Conclusion: UTI can effectively reduce the serum levels of CRP, IL-6, and TNF-α in Asian patients with AP, suggesting that UTI has anti-inflammatory effect on Asian patients with AP.


Author Details

Authors

• Ling-Zhang Wang¹
• Ming-Yu Luo¹
• Jin-Shan Zhang²
• Fu-Gui Ge³
• Jian-ling Chen¹
• Chang-Qing Zheng⁴


Departments

• ¹ Department of Emergency,
• ² Department of Radiology, LinYi People’s Hospital,
• ³ Department of Surgery, Linyi Women’s and Children’s Hospital, LinYi, and
• ⁴ Department of Gastroenterology, Shengjing Hospital, China Medical University, Shenyang, China

Address

Dr. Jian-ling Chen
Department of Emergency, LinYi People’s Hospital
NO.27 Jiefang Road, Lanshan District, LinYi 276000, P.R.China
Email: chenjianling1008@
163.com

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