Abstract

Objective: The effects of age and gender on the single-dose pharmacokinetics of dexloxiglumide, a selective cholecystokinin (CCK₁-subtype) receptor antagonist, were assessed in healthy young and elderly male and female subjects. Methods: In total, 24 males and 24 females (12 young and 12 elderly subjects per gender group) received a single oral dose of 200 mg dexloxiglumide under fasted conditions. Mean (range) ages were 23.8 (18 ? 32) and 71.3 (66 ? 88) years for young and elderly subjects, respectively. Analysis of covariance (ANCOVA) with age group and gender as factors and body weight as a covariate was performed on the dexloxiglumide pharmacokinetic parameters of peak plasma concentration (C_max) and the area under the plasma concentration-time curve (AUC). The p values obtained from ANCOVA were considered for the assessment of age and gender effects. Results: A small (~ 18%) but statistically significant (p

Author Details

Authors

• P. Roy
• J. Wangsa
• A. Patel
• A. Nolting
• St. Persiani
• W. Abramowitz
• R. Kapil

Departments

• ¹ Department of Clinical Pharmacology and Drug Dynamics, Forest Research Institute, Harborside Financial Center, New Jersey, USA,
• ² Department of Bioanalytical and Drug Metabolism, Forest Research Institute, Farmingdale, New York, USA,
• ³ Rotta Research Labor

Address

R. Kapil, PhD Forest Research Institute Harborside Financial Center, Plaza V Jersey City, NJ 07311, USA
Email: [email protected]

Citation