Effects of supplementation with curcuminoids on serum copper and zinc concentrations and superoxide dismutase enzyme activity in obese subjects
Afsaneh Mohajer1, Majid Ghayour-Mobarhan2, Seyed Mohammad Reza Parizadeh1, Shima Tavallaie1, Majid Rajabian3, Amirhossein Sahebkar4
1 Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, 2 Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, 3 Department of Biology, Payame Noor University of Tehran, Tehran, and 4 Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
DOI 10.5414/TEX01363
Abstract
Background: Oxidative stress and imbalances in trace element status have been proposed as emerging risk factors for coronary heart disease (CHD). The present study aimed to determine serum concentrations of zinc (Zn), copper (Cu) and their ratio, as well as activities of superoxide dismutase (SOD) enzyme following supplementation with curcuminoids in obese subjects. Methods: 30 obese subjects were randomly allocated to receive curcuminoids (1 g/day; co-supplemented with piperine (10 mg/day) to improve bioavailability of curcuminoids) or matching placebo for 4 weeks, followed by a 2-week wash-out period and subsequent crossing over to the alternate treatment. Serum levels of Cu, Zn, Zn/Cu, Cu/Zn, and SOD activities were determined 4 times for each subject i.e., at the start and end of treatment with curcuminoids and placebo. Results: Supplementations with curcuminoids was associated with a significant increase in serum Zn/Cu and a reduction in Cu/Zn. However, no significant alteration was observed in serum concentrations of Zn and Cu, nor in SOD activities. Conclusion: Short-term supplementation with curcuminoids improves serum Zn/Cu ratio. This effect may justify part of the reported cardioprotective effects of curcuminoids.
Author Details
Authors
Departments
- 1 Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad,
- 2 Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad,
- 3 Department of Biology, Payame Noor University of Tehran, Tehran, and
- 4 Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Address
Majid Ghayour-Mobarhan, MD, MSc, PhD
Biochemistry of Nutrition Research Center
Faculty of Medicine
Mashhad University of Medical Sciences
Mashhad 9177948564, Iran
or
Amirhossein Sahebkar, PharmD, PhD
Biotechnology Research Center
Mashhad University of Medical Sciences
Mashhad 9177948564, Iran
Email:
[email protected] or [email protected]
Citation
Afsaneh Mohajer, Majid Ghayour-Mobarhan, Seyed Mohammad Reza Parizadeh, Shima Tavallaie, Majid Rajabian, and Amirhossein Sahebkar.Effects of supplementation with curcuminoids on serum copper and zinc concentrations and superoxide dismutase enzyme activity in obese subjects. 2015; 32: 16-21. doi: 10.5414/TEX01363.
