Abstract

Objective: To determine the CYP2D6 phenotype in a Greek population by using dextromethorphan (DM) as a probe drug. Methods: DM (30 mg) was given orally to 102 unrelated Greek subjects and 8-hour urine samples were collected. Concentrations of DM and its metabolite dextrorphan (DX) were determined using a validated HPLC assay. Metabolic molar ratio (MR) of DM to free DX in log form was used as an in vivo index of metabolic status. Results: The frequency distribution histogram of MR was bimodal. An antimode of 0.25 for the mean log MR was determined using probit analysis. Seven of 102 subjects (6.9%) were poor metabolizers (PMs). Conclusion: The PM frequency of CYP2D6 in Greek subjects was similar to other Caucasian populations.

Author Details

Authors

• V.K. Kimiskidis
• I. Niopas
• P.D. Firinidis
• F.I. Kanaze
• C. Gabrieli
• D. Kazis
• S. Papagiannopoulos
• A. Kazis

Departments

• ¹ Department of Neurology, George Papanicolaou Hospital, Aristotle University, and
• ² Department of Pharmacy, Aristotle University, Thessaloniki, Greece

Address

Dr. I. Niopas Department of Pharmacy School of Health Sciences Aristotle University 54124 Thessaloniki, Greece
Email: [email protected]

Citation