Imbalance of serum trace elements in acute leukemia contributes to pro and anti-oxidative stress via ROS and SOD regulation: a population based study
Ali Tahir1, Ahmed Ashfaq2, Ahsan Khuram Aqeel2, Yasmeen Nuzhat3, Allah Rakha Sobia2, Murtaza Iram1
1 Signal Transduction Lab, Department of Biochemistry, Quaid-i-Azam University, Islamabad, 2 Experimental Physics Lab, National Centre for Physics, Quaid-i-Azam University, Islamabad, and 3 Oncology Department, Pakistan Institute of Medical Sciences, Sector G- 8 / 3 , Islamabad, Pakistan
DOI 10.5414/TEX01358
Abstract
Background: In the Pakistani population the number of leukemia patients is increasing constituting a serious concern which needs to be addressed. Previous studies have shown the role of trace elements in diverse physiological and pathological systems, but major effects as are leading cause of leukemia in Pakistani population are still not addressed. The present investigation was aimed at determining the level of oxidative stress regulating trace elements (Fe, Zn, Cu and Ni) as well as ROS and SOD status in acute leukemia patients from the Pakistani population. Methods: 60 acute leukemia (AML, ALL each 30) patients and 30 control individuals were studied. Trace elements concentration was calculated by Flam atomic absorption spectrophotometer (Agilent Technilogies, Berkshire, UK). The ROS and SOD analysis were carried out from serum samples. Result: The concentrations of free radicals in both AML as well as ALL were significantly higher compared to the normal healthy individuals. Serum SOD levels were significantly down regulated in acute leukemia patients. Trace element Fe and Zn concentrations were significantly decreased while the concentrations of Cu and Ni were increased in leukemia patients compared to the normal healthy subjects. Conclusion: Our findings demonstrate significant association between trace elements (Fe, Zn, Cu and Ni) and acute leukemia. Also, the imbalance of serum trace elements contributes to pro and anti-oxidative stress via regulation of ROS and SOD in acute leukemia compared to the normal healthy subjects. Altogether, the present study may open new avenues for designing future treatments for leukemia patients and helping to partially control its life threatening effects.
Author Details
Authors
Departments
- 1 Signal Transduction Lab, Department of Biochemistry, Quaid-i-Azam University, Islamabad,
- 2 Experimental Physics Lab, National Centre for Physics, Quaid-i-Azam University, Islamabad, and
- 3 Oncology Department, Pakistan Institute of Medical Sciences, Sector G-
- 8 /
- 3 , Islamabad, Pakistan
Address
Dr. Murtaza Iram
Signal Transduction Lab
Department of Biochemistry
Quaid-i-Azam University
Islamabad, 45320, Pakistan
Email:
[email protected]
Citation
Ali Tahir, Ahmed Ashfaq, Ahsan Khuram Aqeel, Yasmeen Nuzhat, Allah Rakha Sobia, and Murtaza Iram.Imbalance of serum trace elements in acute leukemia contributes to pro and anti-oxidative stress via ROS and SOD regulation: a population based study. 2015; 32: 22-27. doi: 10.5414/TEX01358.
