Abstract

A 25-year-old woman was admitted because of proteinuria. A renal biopsy showed mesangial/endocapillary proliferative glomerulonephritis with IgG2-κ deposits. Electron microscopy showed immune complex-type deposits. She also had Coombs-positive hemolytic anemia, anticardiolipin antibodies, and antinuclear antibodies. Middle-dose steroid therapy led to improvement of proteinuria and hemolytic anemia. Six years later, she developed crescentic glomerulonephritis with IgG2-κ deposits during pregnancy. Middle-dose steroid therapy improved renal dysfunction. This is an exceptional case of proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID), a recently described rare dysproteinemia-related glomerulonephritis, associated with autoimmune disease. This case also suggests that crescentic glomerulonephritis can be superimposed on PGNMID.

Author Details

Authors

• Takashi Fujiwara¹
• Atsushi Komatsuda¹
• Hiroshi Ohtani²
• Masaru Togashi¹
• Ken-ichi Sawada¹
• Hideki Wakui¹

Departments

• ¹ Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, and
• ² Department of Nephrology and Dialysis, Akita Kumiai General Hospital, Akita, Japan

Address

Atsushi Komatsuda, MD
Department of Hematology, Nephrology, and Rheumatology
Akita University Graduate School of Medicine
1-1-1 Hondo, Akita City, Akita 010-8543, Japan
Email: [email protected]

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