Abstract

We report a case of APN after OSP use in a patient with nephrotic syndrome (NS). Renal biopsy revealed minimal change disease with multifocal calcium phosphate deposits within the tubules and in the interstitium. The serum level of fetuin-A, a systemic calcification inhibitor, was low during severely proteinuric state but normalized after remission of NS. To verify whether fetuin-A levels are low in NS patients, serum fetuin-A levels were determined in 10 patients with NS and 10 with asymptomatic microscopic hematuria (H). The mean serum fetuin-A levels were significantly lower in the NS group compared to the H group (p < 0.01). This finding suggests that a lower serum fetuin-A level may be associated with APN after OSP use in patients with NS, thus careful attention should be paid when colonoscopy using OSP is scheduled in this population.

Author Details

Authors

• S.H. Han¹
• ²*
• J.E. Lee¹*
• S.H. Lee¹
• J.J. Li³
• S.W. Hong⁴
• D.S. Han¹
• S.-W. Kang¹

Departments

• ¹ Department of Internal Medicine, College of Medicine, Brain Korea
• ² 
• ¹  Project for Medical Science, Yonsei University, Seoul,
• ² Department of Internal Medicine, NHIC Ilsan Hospital, Goyangshi, Gyeonggi-do, Korea,
• ³ Department of Internal Medicine, Nephrology and Dialysis Unit, the Affiliated Hospital, YanBian University Medical College, JiLin, China, and
• ⁴ Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
  
  *These two authors contributed equally to this paper.

Address

S.-W. Kang, MD, PhD
Department of Internal Medicine
Yonsei University College of Medicine
134 Shinchon-Dong
Seodaemoon-Gu, Seoul, 120-752, Korea
Email: [email protected]

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