Abstract

Aim: To determine the disease severity at onset and outcome for African-American and Caucasian pediatric patients with IgA nephropathy diagnosed at the Le Bonheur Children’s Medical Center since 1990. Design/Methods: The study population included all patients diagnosed with IgA nephropathy at the Le Bonheur Children’s Medical Center from January 1990 through February 2004. All were below age 18 at biopsy. Clinical features assessed at diagnosis were age, gender, presence of hypertension, history of macroscopic hematuria, degree of proteinuria, severity of renal histology and pattern for immunofluorescent reactants. Statistics: Student’s t-test was used to compare age at biopsy and length of follow-up between the 2 groups. Fisher’s exact test was used to compare features at presentation and patterns of immunofluorescence. Kidney survival was predicted by the Kaplan-Meier method. Results: Forty-seven patients (17 African-American, 29 Caucasian) were studied. Clinical features at diagnosis and pattern for all immunofluorescent reactants did not differ significantly between the 2 groups. Mesangial deposition of C1q occurred in 4/17 African-Americans as compared to 1/27 Caucasians (p = 0.06). Four patients (2 African-Americans, 2 Caucasians) progressed to end-stage renal disease. Predicted kidney survival was 96% (94% in African-Americans and 97% in Caucasians) at 1 year and 91% (94% in African-Americans and 89% in Caucasians) at 5 years from diagnosis. Mean time from diagnosis to end-stage renal disease or last follow-up was 3.3 years (3.8 for African-Americans, 3.0 for Caucasians). Macroscopic hematuria occurred prior to diagnosis for 90% of the Caucasian as compared to 61% of the African-American patients (p = 0.03). Urinalysis was normal at last follow-up visit for 24% of African-American patients and 32% of Caucasian patients. Conclusion: In a relatively small sample from a single center, except for the difference in macroscopic hematuria, clinical features at diagnosis and outcome of IgA nephropathy appear similar for African-American and Caucasian pediatric patients.

Author Details

Authors

• K.K. Lau
• L.W. Gaber
• N.M. Delos Santos
• K.A. Fisher
• S.J. Grimes
• R.J. Wyat

Departments

• ¹ Children’s Foundation Research Center at the Le Bonheur Children’s Medical Center, Departments of
• ² Pediatrics and
• ³ Pathology, University of Tennessee Health Science Center, Memphis, TN, USA

Address

Dr. R.J. Wyatt
Division of Pediatric Nephrology
Room 301 West Patient Tower
Children’s Foundation Research Center
50 N. Dunlap
Memphis, TN 38103, USA
Email: [email protected]

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