Abstract

We report on the management of a 36-year-old hemodialysis patient with heparin-induced thrombocytopenia (HIT, type II) and clot formation in extracorporeal circulation. Platelet aggregation test and measurement of anti-platelet factor 4/heparin complex antibody by enzyme-linked immunosorbent assay revealed to us that our patient had developed HIT. Instead of heparin, we used nafamostat mesilate (NM) as an anticoagulant during hemodialysis, but could not completely prevent HIT-induced thrombocytopenia or clot formation in the extracorporeal circuit. Combined use of NM and aspirin completely inhibited platelet aggregation, decrease in platelet count and clot formation in the extracorporeal circuit.

Author Details

Authors

• H. Takahashi
• S. Muto
• E. Nakazawa
• S. Yanagiba
• Y. Masunaga
• Y. Miyata
• K. Tamba
• E. Kusano
• M. Matsuo
• T. Matsuo
• Y. Asano

Departments

• ¹ Department of Nephrology, Jichi Medical School, Tochigi, and
• ² Department of Central Laboratory and Internal Medicine, Hyogo Prefectural Awaji Hospital, Hyogo, Japan

Address

Log in for Subscribers

Citation