Distribution and absorption of the microcrystalline cisplatin in mice by oral administration
X. Cui1, L.J. Liu2, P. Liu1, J. Sun1
1 Institute of Chemistry and Microbacteria Detection, College of Public Health, West Part of Shandong University, and 2 Institute of Inorganic Chemistry, College of Pharmacy, West Part of Shandong University, Jinan, PR China
DOI 10.5414/TEP20262
Abstract
Absorption, distribution and elimination of both microcrystalline cisplatin and routine cisplatin in mice by oral administration were studied. Concentrations of cisplatin in blood, liver, stomach and kidney of mice were determined by graphite furnace atomic spectrophotometry. After oral administration of microcrystalline cisplatin, cisplatin could reach peak concentrations in stomach, blood, kidney and liver at about 30 min. The stomach had the highest cisplatin level of all determined tissues, and remained high (> 3.42 mg/g) within a duration of 1 h. Compared with the ordinary cisplatin drug, the microcrystalline cisplatin has a higher peak concentration, indicating that microcrystalline cisplatin can be absorbed effectively. Kidney had a higher peak concentration of cisplatin at approximately 45 min than both liver and blood, and the elimination rate remained slow for 4 h. Thus, microcrystalline cisplatin would be a potential orally taken anti-gastric carcinoma drug, but its kidney toxicity should not be neglected.
Author Details
Authors
Departments
- 1 Institute of Chemistry and Microbacteria Detection, College of Public Health, West Part of Shandong University, and
- 2 Institute of Inorganic Chemistry, College of Pharmacy, West Part of Shandong University, Jinan, PR China
Address
Citation
X. Cui, L.J. Liu, P. Liu and J. Sun.Distribution and absorption of the microcrystalline cisplatin in mice by oral administration. 2003; 20: 262-265. doi: 10.5414/TEP20262.
