Abstract

A 32-year-old woman presented with amenorrhea after a normal childbirth and subsequently developed nephrotic syndrome. Renal biopsy showed a thrombotic microangiopathy (TMA)-like glomerular lesion with deposits of immunoglobulins, complements, and fibrinogen. Increased serum levels of the beta subunit of human chorionic gonadotropin, abnormal uterine findings from imaging studies, and endometrial biopsy findings suggested gestational trophoblastic disease. She was diagnosed with a placental site trophoblastic tumor (PSTT) after hysterectomy and, following treatment, her proteinuria disappeared. Follow-up renal biopsy showed the disappearance of the TMA-like lesion. To our knowledge, this is the first case report of the pathological remission of renal disease associated with PSTT.

Author Details

Authors

• Masato Sawamura¹
• Atsushi Komatsuda¹
• Mizuho Nara¹
• Masaru Togashi¹
• Hideki Wakui²
• Naoto Takahashi¹

Departments

• ¹ Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, and
• ² Department of Life Science, Akita University Graduate School of Engineering Science, Akita, Japan

Address

Dr. Atsushi Komatsuda, Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita City, Akita 010-8543, Japan
Email: [email protected]

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