Abstract

Type I membranoproliferative glomerulonephritis (MPGN) is an uncommon manifestation of human immunodeficiency virus (HIV)-associated renal disease in patients co-infected with hepatitis C virus (HCV). We describe a case of Type I MPGN in an HIV-positive diabetic man with nephrotic-range proteinuria and renal insufficiency who was not co-infected with HCV. Tubuloreticular inclusions were present but there was no evidence for either cryoglobulinemia or cryoglobulin deposits in the kidney. This finding suggests that Type I MPGN may represent a reaction of the kidney to HIV independent of the effects of HCV co-infection. Clinical suspicion must be maintained for Type I MPGN in all HIV infected patients presenting with significant proteinuria regardless of HCV infection status.

Author Details

Authors

• M. Chidambaram
• C.E. Stigant
• L.M. Sugar
• G.V. Ramesh Prasad

Departments

• ¹ Department of Medicine,
• ² Department of Pathology, St. Michael?s Hospital, University of Toronto, Toronto, Ontario, Canada

Address

Citation