Abstract

Vincristine (VCR) is an important drug used in the treatment of acute lymphoblastic leukemia (ALL). VCR-induced neurotoxicity can manifest as peripheral neuropathy, constipation, or paralytic ileus. While there are some case reports describing VCR-induced paralytic ileus (VIPI) in pediatric ALL, there are fewer publication on adult ALL patients. Therefore, we retrospectively investigated VIPI during induction therapy of treatment protocols for ALL in 19 adult patients. The incidence of VIPI was 32%. VIPI was significantly increased in patients receiving concomitant itraconazole (ITCZ) (p = 0.04). We recommend avoidance of the combination of VCR and ITCZ.

Author Details

Authors

• Takeo Yasu¹
• Nobuhiro Ohno²
• Toyotaka Kawamata²
• Yosuke Kurokawa¹

Departments

• ¹ Department of Pharmacy, and
• ² Department of Hematology/Oncology, The Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Address

Takeo Yasu, PhD
The Research Hospital
The Institute of Medical Science
The University of Tokyo
4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
Email: [email protected]

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