Abstract

Objective: To formulate and evaluate a pharmacodynamic model that characterizes the effects of S-verapamil on the circadian 24-hour ambulatory blood pressure (ABP). Methods: ABP was recorded in 19 hypertensive patients off drug, and following administration of the targeted dose of COER-V given once daily for at least 30 days. Blood samples were collected after the last dose for determination of the pharmacokinetic of S-verapamil. ABP vs. time was analyzed using a cosinor function, and the effects of S-verapamil on ABP were fitted using the pharmacodynamic model. Results: COER-V decreased average systolic and diastolic blood pressures (mesors): baseline, 142

Author Details

Authors

• J.J. Lima
• B. Nhi Beasley
• R.B. Parker
• J.A. Johnson

Departments

• ¹ Center for Clinical Pediatric Pharmacology & Pharmacogenetics, Nemours Children?s Clinic, Jacksonville, FL,
• ² University of Tennessee College of Pharmacy, Memphis, TN,
• ³ Food and Drug Administration, Center for Drug Evaluation and Research, Rockville, MD

Address

J.J. Lima, Pharm. D. Center for Clinical Pediatric Pharmacology & Pharmacogenetics Nemours Children?s Clinic 807 Nira Street Jacksonville, FL 32207, USA
Email: [email protected]

Log in for Subscribers

Citation