Abstract

Objective: Obesity is associated with an increased risk of chronic kidney disease (CKD), but the best anthropometric obesity measure remains controversial. This study aimed to examine the associations of anthropometric indexes with CKD risk and which anthropometric index is a better predictor of CKD. Methods: Data was drawn from a cross-sectional study in China. We used four anthropometric indexes: body mass index (BMI), waist circumference (WC), waist-tohip ratio (WHR), and waist-to-height ratio (WHtR). CKD was defined as estimated glomerular filtration rate (eGFR) < 60 ml/ min/1.73 m² or urinary albumin to creatinine ratio (ACR) ≥ 30 mg/g. Logistic regressions were used for the analyses. Results: 1,834 participants were included in the analyses. After adjusting for potential confounders, BMI, WC and WHtR were significantly associated with CKD in men and women. The respective odd ratios for BMI (every SD increment), WC (every SD increment), and WHtR (every SD increment) were 1.46, 1.40, and 1.45 in men as well as 1.21, 1.31, and 1.38 in women. After adjusting for potential confounders, WHR was associated with CKD in women but not men. In women, the associations of WC, WHR and WHtR with CKD was independent of other MetS components. No difference in WHtR was observed between men and women. Conclusion: Anthropometric indexes are associated with CKD. The associations of anthropometric indexes with CKD are independent of other MetS components in women but not men. In women, central obesity indexes are better than BMI for predicting of CKD.

*Both authors contributed equally.

Author Details

Authors

• Shanying Chen¹
• ²*
• Bide Wu²*
• Xinyu Liu¹
• Youming Chen³
• Yongqiang Li¹
• Mi Li⁴
• Yan Liang¹
• Xiaofei Shao¹
• Harry Holthöfer⁵
• Hequn Zou¹

Departments

• ¹ Department of Nephrology, the Third Affiliated Hospital of Southern Medical University, Guangzhou,
• ² Department of Nephrology, Zhangzhou Municipal Affiliated Hospital of Fujian Medical University, Zhangzhou,
• ³ Clinical laboratory, the Third Affiliated Hospital of Southern, Medical University, Guangzhou,
• ⁴ Blood purification center, No.
• ⁵  Affiliated Hospital of Sun Yat-sen University, Zhuhai, China, and
• ⁵ National Centre for Sensor Research/BioAnalytical Sciences, Dublin City University, Ireland

Address

Hequn Zou, MD
Department of Nephrology
The Third Affiliated Hospital of
University of Southern Medical University
183# Zhongshan Dadao, Tianhe district
Guangzhou, 510000 P. R. China
Email: [email protected]

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