Abstract

The aim of this retrospective study of a series of patients with mesial temporal lobe epilepsy (MTLE) and mesial temporal sclerosis (MTS) was to analyze the association of granule cell dispersion (GCD) with surgical prognosis, patterns of MTS and clinical data. Hippocampal specimens from 66 patients with MTLE and unilateral MTS and from 13 controls were studied. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patients’ clinical data, types of MTS and surgical outcome were reviewed. GCD occurred in 45.5% of cases and was not correlated with clinical variable. More severe neuronal loss was observed in patients with GCD. Except for MTS Type 2 – observed only in four no- GCD patients – groups did not differ with respect to the types of MTS. Surgical outcome was similar in both groups. In conclusion, GCD was associated with the degree of hippocampal cell loss, but was not a predictor of surgical outcome.

Author Details

Authors

• Rafael Scarpa da Costa Neves¹*
• Anaclara Prada Jardim¹*
• Luís Otávio Caboclo¹
• Carmen Lancellotti²,³
• Taissa Ferrari Marinho¹
• Ana Paula Hamad¹
• Murilo Marinho¹
• Ricardo Centeno¹
• Esper Abrão Cavalheiro⁴
• Carla Alessandra Scorza⁴
• Elza Márcia Targas Yacubian¹

Departments

• ¹ Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, Escola Paulista de Medicina,
• ² Department of Pathology, Santa Casa de São Paulo,
• ³ Department of Pathology, Associação Fundo de Incentivo à Pesquisa (AFIP), Medical Diagnosis and
• ⁴ Department of Neurology and Neuroscience, Experimental Neurology, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo SP, Brazil
  
  *The authors contributed equally to this study.

Address

Rafael Scarpa da Costa Neves
Unidade de Pesquisa e Tratamento das Epilepsias
Rua Napoleão de Barros 737 – 13º andar
04024-002 São Paulo, SP – Brasil
Email: [email protected]

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