Abstract

Primary diffuse leptomeningeal gliomatosis (PDLG) is characterized by diffuse infiltration of the leptomeningeal space by neoplastic glial cells without evidence of intra-parenchymatous primary tumor. We report a case of PDLG in a 68-year-old man, who died 1 month after onset of symptoms. The diagnosis was made on autopsy data. We discuss the particularities of this entity, which is not registered in the WHO classification of tumors of the central nervous system (2016). In case of an unexplained inflammatory meningeal process and in the presence of atypical cells in the cerebrospinal fluid, PDLG needs to be considered. This diagnosis of PDLG has to be confirmed by meningeal imaging-guided biopsy, which must be repeated if necessary.


Author Details

Authors

• Sébastien Lepreux¹
• Sharmilla Sagnier²
• Jean-Thomas Perez¹
• François Léger¹
• Igor Sibon²
• Anne Vital¹

Departments

• ¹ Pathology Department and
• ² Neurology Department, Bordeaux University Hospital, France

Address

Sébastien Lepreux, MD, PhD
Pathology Department, CHU Bordeaux Pellegrin
Place Amélie Raba-Leon
33076 Bordeaux Cedex, France
Email: [email protected]

Citation