Abstract

Lowered Mg⁺⁺ stores in humans seem to be involved in the pathogenesis of essential hypertension. However, some antihypertensive drugs (e.g. in particular diuretics) can additionally decrease plasma or intracellular Mg⁺⁺ stores. In this context, the role of the new antihypertensive angiotensin II antagonists has not been studied in detail as yet, as long-term studies have not already been performed yet. In the study presented here, 20 essential hypertensive patients were monotreated with various angiotensin II antagonists (eprosartan, irbesartan, lorsatan, valsartan, candesartan). In each patient, plasma Mg⁺⁺ concentrations were studied before, under, and after therapy (36 ± 3 months). The results showed no significant difference in plasma Mg⁺⁺ and K⁺ concentrations in essential hypertensives before, under, and after a long-term treatment with various sartans. In conclusion, a monotherapy with various angiotensin II antagonists concerning Mg⁺⁺ and K⁺ handling is safe and reduces blood pressure significantly.

Author Details

Authors

• K. Kisters¹
• V. Rempel¹
• I. Kabar¹
• M. Cziborra¹
• C. Funke¹
• F. Wessels¹
• F. Tokmak²
• B. Gremmler³
• J. Büntzel⁴
• H. Liebscher⁴
• M. Hausberg⁴

Departments

• ¹ Medizinische Klinik I, St. Anna Hospital Herne,
  
• ² Nephrologie, Marienhospital Herne, Ruhr Universität Bochum,
• ³ Kardiologie, Marienhospital Bottrop and
• ⁴ AKTE, Bielefeld, Germany

Address

Prof. Dr. K. Kisters
Medizinische Klinik I, St. Anna-Hospital, Hospitalstraße 19, 44649 Herne, Germany
Email: [email protected]

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