Association between perioperative diuretic use and postoperative outcomes following Mohs micrographic surgery
Nehaa Sohail1, Sabrina Zheng1, Zuhair Zaidi2, Ayaan Sohail3, Wesam Abdel-Jaber1, Inaaya Lodhi4, Sino Mehrmal5, Misha V. Koshelev6, Biff F. Palmer1
1 Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, 2 UT Southwestern Medical School, Dallas, 3 John P. and Kathrine G. McGovern Medical School, University of Texas Health Science Center at Houston, Houston, 4 University of North Texas, Denton, TX, 5 Epiphany Dermatology, St. Louis, MO, and 6 Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA
DOI 10.5414/CN112145
Abstract
Patients undergoing Mohs micrographic surgery (MMS) on perioperative diuretics represent a medically complex population, yet the impact of diuretic use on postoperative outcomes remains underexplored. Despite use in patients with cardiometabolic comorbidities, limited research has evaluated how perioperative diuretic exposure influences postoperative outcomes following MMS. This study investigates the association between perioperative diuretic use and postoperative outcomes following MMS. Utilizing the TriNetX database, MMS patients were matched on a 1 : 1 basis according to perioperative diuretic use. Outcome variables were evaluated over a 30- and 90-day follow-up period. Among 37,781 matched patients, diuretic use was associated with higher odds of surgical site infection at both 30 days (OR 1.29, 95% CI 1.03 – 1.62, p = 0.03) and 90 days (OR 1.36, 95% CI 1.12 – 1.65, p < 0.001), as well as substantially increased odds of rash or cellulitis at 30 days (OR 1.95, 95% CI 1.68 – 2.26, p < 0.001) and 90 days (OR 1.92, 95% CI 1.74 – 2.13, p < 0.001). Perioperative diuretic use was linked to increased odds of infection, rash or cellulitis, postoperative pain, opioid use, emergency department visits, sepsis, and short-term mortality, with time-to-event analysis identifying loop and osmotic diuretics as the primary drivers of risk.
Author Details
Authors
Departments
- 1 Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso,
- 2 UT Southwestern Medical School, Dallas,
- 3 John P. and Kathrine G. McGovern Medical School, University of Texas Health Science Center at Houston, Houston,
- 4 University of North Texas, Denton, TX,
- 5 Epiphany Dermatology, St. Louis, MO, and
- 6 Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA
Address
Nehaa Sohail, MBA
5001 El Paso Drive
El Paso, TX 79905, USA
Email:
[email protected]
Citation
Nehaa Sohail, Sabrina Zheng, Zuhair Zaidi, Ayaan Sohail, Wesam Abdel-Jaber, Inaaya Lodhi, Sino Mehrmal, Misha V Koshelev, Biff F Palmer. Association between perioperative diuretic use and postoperative outcomes following Mohs micrographic surgery
. Clin Nephrol. 2026;
106:
379-
385.
doi: 10.5414/CN112145.
Pubmed:
https://pubmed.ncbi.nlm.nih.gov/42610551/;
PMID: 42610551.
