Abstract

Background: There is evidence that Bu-Shen-Jian-Pi (BSJP), a traditional Chinese medicine, has curative effects in patients suffering from amyotrophic lateral sclerosis (ALS), a progressive and potentially fatal hypoxic condition.
Objective: To identify biogenic components in BSJP extracts having potential pharmacological efficacy in ALS.
Materials and methods: Biogenic components in BSJP and their potential pharmacological targets and signaling pathways in ALS were identified and assessed using network pharmacology/hub node analysis.
Results: Network pharmacology analysis identified icariin, naringenin, kaempferol, quercetin, and formononetin as core components in BSJP with potential activity involving mitochondrial protection in patients with ALS.
Conclusion: Network pharmacology analysis proved to be a successful screening tool for obtaining information from scientific databases on the pharmacology of biogenic components in BSJP showing potential therapeutic activity in ALS.

*Contributed equally.

Author Details

Authors

• Jiacheng Lin¹*
• Jun Wang²*
• Chenghui Wang²
• Yuetong Shan²
• Wei Jing²
• Zhimin Fei^{3, 4}
• Weidong Pan^{2, 4, 5}

Departments

• ¹ Central Laboratory, Science and Technology Laboratory Center,
• ² Deparment of Neurology,
• ³ Department of Neurosurgery,
• ⁴ Encephalopathy Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, and
• ⁵ First Department of Encephalopathy, Anhui Provincial Hospital of Integrated Chinese and Western Medicine (The Third Affiliated Hospital of Anhui University of Chinese Medicine), Anhui, China

Address

Professor Zhimin Fei, MD
or
Professor Weidong Pan, MD, PhD
528, Pudong, New Areas
201203 Shanghai, China
Email: [email protected]; [email protected]

Log in for Subscribers

Citation