Abstract

Objective: To understand the effect of prolonged intravenous acetaminophen infusion on blood pressure.
Materials and methods: We retrospectively studied a cohort of intensive care patients receiving initial intravenous acetaminophen. We used propensity score matching to adjust for differences between patients who were classified into two groups: control (acetaminophen infusion for 15 minutes) and prolonged administration (acetaminophen infusion for > 15 minutes).
Results: After acetaminophen administration, diastolic blood pressure was unchanged in the control group, and was significantly lower at 30 and 60 minutes in the prolonged administration group.
Conclusion: Prolonged duration of acetaminophen infusion did not prevent acetaminophen-induced blood pressure reduction.

Author Details

Authors

• Yasunori Urayama¹
• Satoshi Kosaka¹
• Tsugumi Ide¹
• Mikio Shirota^{1, 3}
• Takeo Yasu^{1, 2, 3}

Departments

• ¹ Department of Pharmacy, Tokyo Metropolitan Bokutoh Hospital, Kotobashi, Sumida-ku,
• ² Department of Medicinal Therapy Research, Pharmaceutical Education and Research Center, Meiji Pharmaceutical University, Noshio, Kiyose, and
• ³ Bokutoh Hospital-Meiji Pharmaceutical University Joint Research Center, Kotobashi, Sumida-ku, Tokyo, Japan

Address

Takeo Yasu, PhD
Department of Medicinal Therapy Research
Pharmaceutical Education and Research Center
Meiji Pharmaceutical University
2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan
Email: [email protected]

Citation