Abstract

Hereditary spastic paraparesis (HSP) caused by mutations in the SPAST (SPG4) gene are autosomal-dominant inherited disorders characterized by weakness of lower extremities, spasticity and hyperreflexia. Some cases with cognitive decline have been repored. Herein we present an asymptomatic carrier of a SPAST gene mutation who developed an adult-onset cognitive decline, compatible with Alzheimer’s disease with co-pathologies such as argyrophylic grain disease and cerebrovascular pathology. No pathological changes described in HSP patients were present in this case.

Author Details

Authors

• Sara Forcén¹
• Ane Miren Crespo Cuevas¹
• Iban Aldecoa^{2, 3}
• Oscar Ramos²
• Lourdes Ispierto¹
• Ramiro Álvarez¹
• Dolores Vilas¹

Departments

• ¹ Movement Disorders Unit, Neurology Department, Hospital Universitari Germans Trias i Pujol, Badalona,
• ² Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, and
• ³ Pathology Department, Biomedical Diagnostic Center, Hospital Clinic, Barcelona, Spain

Address

Dolores Vilas Rolán, MD, PhD
Neurodegenerative Diseases Unit
Neurology Department
Hospital Universitari Germans Trias i Pujol
Carretera Canyet s/n, 08916 Barcelona, Badalona, Spain
Email: [email protected]

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