Abstract

We describe a case of a patient treated for cognitive dysfunction (CD) with suspected thiamine deficiency (TD). A 74-year-old man with gastric cancer presented with grade 3 diarrhea and grade 1 anorexia. He had been receiving trastuzumab plus tegafur (a chemotherapeutic fluorouracil prodrug), gimeracil, and oteracil (S-1) and oxaliplatin. On admission, cognitive function was assessed with the Hasegawa’s Dementia Scale (HDS-R) because he had impaired short-term memory. His thiamine levels increased from 22 to 109 ng/mL after administration of 75 mg of thiamine. Furthermore, the patient’s HDS-R score improved from 9 to 22, and cognitive and memory functions improved. TD should be considered in older CD patients receiving oral chemotherapy agents including fluorouracil.

Author Details

Authors

• Yohei Iimura¹
• Takeo Yasu^{1, 2}
• Kenji Momo^{1, 3}
• Seiichiro Kuroda¹
• Yoshiaki Kanemoto⁴
• Kentaro Yazawa⁴
• Giichiro Tsurita⁴

Departments

• ¹ Department of Pharmacy, Research Hospital,
• ² Department of Medicinal Therapy Research, Meiji Pharmaceutical University,
• ³ Department of Hospital Pharmaceutics, School of Pharmacy, Showa University, and
• ⁴ Department of Surgery, IMSUT Hospital, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Address


Yohei Iimura, Bsc.

Department of Pharmacy, The Research Hospital
The Institute 
of Medical Science
The University of Tokyo
4-6-1, Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan
Email: [email protected]

Citation