Dustri Online Services

Int. Journal of Clinical Pharmacology and Therapeutics, Volume 56 (2018) - November (551 - 554)

NSAIDs may prevent EGFR-TKI-related skin rash in non-small cell lung cancer patients 
Yohei Iimura¹, Hitoshi Shimomura¹, Takeo Yasu², Keiko Imanaka¹, Ryuichi Ogawa³, Akihiko Ito⁴, Kenichi Suzuki⁵, Gaku Yamaguchi⁶, Norihisa Kawasaki⁶, Chimori Konaka⁶
¹ Department of Pharmacy, International University of Health and Welfare Ichikawa Hospital, Chiba, ² Department of Pharmacy, The Institute of Medical Science, The University of Tokyo, ³ Department of Pharmacotherapy, Meiji Pharmaceutical University, ⁴ Department of Medicinal Therapy Research, Meiji Pharmaceutical University, ⁵ Department of Pharmacotherapy, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, and ⁶ Department of Respiratory Surgery, International University of Health and Welfare Ichikawa Hospital, Chiba, Japan

DOI 10.5414/CP203323

Abstract

Objectives: Skin rash is a common adverse event induced by epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). Here, we aimed to predict factors that reduce EGFR-TKI-related skin rash. Materials and methods: We conducted a single-center, retrospective study to predict factors that reduce skin rash in patients undergoing treatment for non-small cell lung cancer (NSCLC) with EGFR-TKIs using Cox proportional hazards model. Results: Cox proportional hazard analysis revealed that coadministration of non-steroidal anti-inflammatory drug (NSAID) had protective effects against rash. Steroid coadministration showed a trend to being effective in reducing rash. Conclusion: NSAIDs may be useful in preventing EGFR-TKI-related skin rash. 

Author Details

Authors

Departments

¹ Department of Pharmacy, International University of Health and Welfare Ichikawa Hospital, Chiba,
² Department of Pharmacy, The Institute of Medical Science, The University of Tokyo,
³ Department of Pharmacotherapy, Meiji Pharmaceutical University,
⁴ Department of Medicinal Therapy Research, Meiji Pharmaceutical University,
⁵ Department of Pharmacotherapy, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, and
⁶ Department of Respiratory Surgery, International University of Health and Welfare Ichikawa Hospital, Chiba, Japan

Address

Yohei Iimura, BSc
Department of Pharmacy
International University of Health and
Welfare Ichikawa Hospital
6-1-14 Kounodai, Ichikawa-shi, Chiba 272-0827, Japan 
Email: [email protected]

Citation

Yohei Iimura, Hitoshi Shimomura, Takeo Yasu, Keiko Imanaka, Ryuichi Ogawa, Akihiko Ito, Kenichi Suzuki, Gaku Yamaguchi, Norihisa Kawasaki, and Chimori Konaka.NSAIDs may prevent EGFR-TKI-related skin rash in non-small cell lung cancer patients . 2018; 56: 551-554. doi: 10.5414/CP203323.

Shopping Overview

Shopping Overview
Type	Qtty	Discount	VAT	Price
Your basket is empty

View Cart