Abstract

This article reports the case of a 33-year-old woman with common variable immunodeficiency (CVI) who developed renal failure 17 years after diagnosis and initiation of treatment with monthly IVIG. A renal biopsy revealed mesangial and paramesangial immune complex deposition and interstitial granulomatous infiltration. Renal function improved with oral corticosteroids, but did not return to normal. Decreasing the dose of IVIG had no effect on renal function. Immune dysfunction can be associated with both granulomatous disease and immune complex glomerulonephritis, or the latter may be related to chronic infection or immunoglobulin use. This is the first report of concomitant glomerular-tubulointerstitial lesions in this immunodeficiency syndrome. Renal function should be closely followed in patients with CVI.

Author Details

Authors

• C. Stigant
• D. Sapir
• J. Sweet
• G.Downey
• J. Bargman

Departments

• ¹ Nephrology Fellow, University of Toronto,
• ² Staff Pathologist, Toronto General Hospital,
• ³ Faculty of Medicine, University of Toronto, Division of Nephrology, Toronto General Hospital, University Health Network, Toronto

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Citation