Abstract

Cetuximab is a chimeric human-murine monoclonal antibody that binds competitively and with high affinity to the epidermal growth factor receptor (EGFR) and is used to treat advanced squamous cell carcinoma of the head and neck. After receiving a total of six doses of cetuximab, a 72-year-old male presented with pretibial edema, acne-like skin rash, and nephrotic syndrome. The renal biopsy findings revealed features of thrombotic microangiopathy (TMA), with the expansion of the subendothelial zone, reduplication of the glomerular basement, and swelling of the endothelial cells. Nine weeks after the discontinuation of cetuximab, his pretibial edema had disappeared and proteinuria decreased. To our knowledge, this is the first report in which kidney biopsy revealed evidence of TMA due to cetuximab administration. Our report suggests that it may be prudent to monitor patients receiving cetuximab closely for the possible development of nephrotic syndrome.


Author Details

Authors

• Mitsuteru Koizumi
• Masahiro Takahashi
• Maki Murata
• Yuko Kikuchi
• Koichi Seta
• Kensei Yahata


Departments

• Department of Nephrology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan

Address

Mitsuteru Koizumi, MD
Department of Nephrology
National Hospital Organization Kyoto Medical Center
1-1 Fukakusa, 
Mukaihata-cho, Fushimi-ku,
Kyoto 612-8555, Japan

Email: mit-koiz@
rb4.so-net.ne.jp

Citation