Volume 43, No. 12/2005(December)
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Int. Journal of Clinical Pharmacology and Therapeutics
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Index
Contents for Volume 43
Index
Author index
Index
Subject index
Pharmacodynamics
The ability of statins to protect low density lipoprotein from oxidation in hypercholesterolemic patients
Abstract
C. Thallinger, E. Urbauer, E. Lackner, U. Graselli, K. Kostner, M. Wolzt and C. Joukhadar
1Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, 2Department of Internal Medicine II, Division of Cardiology, and 3Department of Internal Medicine I, Division of Infectious Disease and Chemotherapy, Medical University of Vienna
Objective: It is unclear at the present time whether hydroxy-methylglutaryl coenzyme A reductase inhibitors (HMG-CoA reductase inhibitors; statins) exert a protective effect on low-density lipoproteins (LDL) oxidation in vivo. In addition, it is speculated that pharmacological differences between statins may account for differences in their antioxidative capacities. This is of clinical relevance, because there is strong evidence that oxidized LDL initiates the atherosclerosis process. Material and methods: In a controlled, randomized, double-blind study we compared the effects of three different statins (simvastatin, pravastatin and atorvastatin) on the ability to protect LDL from oxidation in 70 hypercholesterolemic but otherwise healthy subjects. Statins were administered in doses which were nearly equi-effective in lowering LDL-cholesterol. Changes in LDL oxidation were measured using diene conjugation (DIENES) and thiobarbituric acid reactive substances (TBARS) at entry and three months after beginning therapy with the statins. Results: Levels of DIENES, usually generated during the early phases of lipid peroxidation, were significantly reduced by 10.2 Correspondence to:
Dr. C. Joukhadar
Department of Clinical Pharmacology
Division of Clinical Pharmacokinetics
Medical University of Vienna
W
Email: christian.joukhadar@meduniwien.ac.at
Case report
Acute pancreatitis associated with omeprazole
Abstract
S.S. Youssef, S.B. Iskandar, J. Scruggs and T.M. Roy
James H. Quillen Veterans Affairs and James H. Quillen College of Medicine, Johnson City, TN, USA
Since their introduction in the late 1980s, proton pump inhibitors (PPI) have demonstrated gastric acid suppression superior to that of histamine H2-receptor blockers. This class of drugs has improved the treatment of various acid-peptic disorders, including gastroesophageal reflux disease, peptic ulcer disease, and nonsteroidal anti-inflammatory drug-induced gastropathy. PPIs have minimal side effects and few significant drug interactions. They are generally considered safe for long-term treatment. We present a rare side effect, acute pancreatitis, occurring in a patient who was treated with the proton pump inhibitor omeprazole.Correspondence to:
S.B. Iskandar, MD
2 Professional Park Drive, Suite 15
Johnson City, TN 37604, USA
Email: drsiskandar@hotmail.com
Pharmacokinetics
The pharmacokinetics of zinc from zinc gluconate: a comparison with zinc oxide in healthy men
Abstract
M. Siepmann, S. Spank, A. Kluge, A. Schappach and W. Kirch
1Institute of Clinical Pharmacology, Medical Faculty, Technical University, Dresden, 2ABX-CRO advanced pharmaceutical services, Dresden, and 3Dr. Gerhard Mann Pharma, Berlin, Germany
Objective: Zinc supplementation is beneficial in some clinical conditions such as age-related macula degeneration (AMD). It has been suggested that zinc absorption is influenced by the form in which zinc is ingested. Therefore, the pharmacokinetics of zinc gluconate (organic) were compared with those of zinc oxide (inorganic). Methods: 12 healthy male subjects aged between 21 and 31 years (24 years median) orally received daily doses of 20 mg metal zinc as zinc gluconate and 17.4 mg metal zinc as zinc oxide under randomized crossover conditions for 14 days each with at least 14 days as a washout. Zinc plasma concentrations were measured by means of inductively coupled plasma-atomic emission spectroscopy. Results: Cmax was found 18.3% (10.3 ? 26.3%) higher following multiple-dose administration of zinc gluconate as compared to zinc oxide (mean; 0.95% confidence interval of the relative differences between both treatment conditions; p < 0.05). AUC0?24h was noted 8.1% (1.9 ? 14.3%) higher after zinc was given as zinc gluconate when compared to zinc oxide (p < 0.05) whereas tmax did not differ between both treatment conditions. Conclusions: Zinc absorption in humans could be improved by zinc complexation with gluconate.Correspondence to:
PD Dr. M. Siepmann
Institut f
Email: Martin.Siepmann@mailbox.tu-dresden.de
Extended Abstracts
Annual Meeting of the Working Group for Pharmacology in Oncology and Hematology (APOH) of the Central European Society for Anticancer Drug Research (CESAR) during the Symposium ?Novel Approaches for the Discover
Extended Abstracts
Pemetrexed: mRNA expression of the target genes TS, GARFT and DHFR correlates with the in vitro chemosensitivity of human solid tumors
Abstract
U. Eismann, O. Oberschmidt, M. Ehnert, J. Fleeth, F.E. L
Extended Abstracts
In vitro investigation on the selectin binding mechanisms in tumor cell metastasis and their inhibition by heparin
Abstract
J. Fritzsche, I. H
Extended Abstracts
Individual variation in factors affecting the steps between dose application and effects of antineoplastic agents
Abstract
U. Fuhr and J. Kirchheiner
Extended Abstracts
Rational development of oxaliplatin analogues ? synthesis and preliminary structure-activity relationships
Abstract
M. Galanski, L. Habala, A.A. Nazarov, M.A. Jakupec, A. Yasemi, S. Slaby, N. Graf v. Keyserlingk and B.K. Keppler
Extended Abstracts
Current pharmacogenetics in colorectal cancer ? do they have an impact on our clinical treatment strategies?
Abstract
E. Goekkurt and J. Stoehlmacher
Extended Abstracts
Identification of new genes involved in cisplatin resistance and their expression profile in 18 human tumor cell lines
Abstract
E.M. Gosepath, S. Weykam, M. Wiese and M.U. Kassack
Extended Abstracts
Targeting of immunoliposomes to endothelial cells expressing VCAM: a future strategy in cancer therapy
Abstract
S. Gosk, C. Gottstein and G. Bendas
Extended Abstracts
Interactions of a novel ruthenium-based anticancer drug (KP1019 or FFC14a) with serum proteins ? significance for the patient
Abstract
C.G. Hartinger, S. Hann, G. Koellensperger, M. Sulyok, M. Groessl, A.R. Timerbaev, A.V. Rudnev, G. Stingeder and B.K. Keppler
Extended Abstracts
A new oxygen-enriched solution enables human tumor tissue transport without cell devitalization
Abstract
M. Heim, R.A. Hilger, H. Ruebben, M. Scharifi, S. Kredtke, D. Thyssen, F. Bach and S. Seeber
Extended Abstracts
Pharmacokinetics (PK) of a liposomal encapsulated fraction containing doxorubicin and of doxorubicin released from the liposomal capsule after intravenous infusion of Caelyx?/Doxil
Abstract
R.A. Hilger, H. Richly, M. Grubert, C. Oberhoff, D. Strumberg, M.E. Scheulen and S. Seeber
Extended Abstracts
Early results from a phase I study on orally administered tris(8-quinolinolato)gallium(III) (FFC11, KP46) in patients with solid tumors ? a CESAR study (Central European Society for Anticancer Drug Research ? EW
Abstract
R.-D. Hofheinz, C. Dittrich, M.A. Jakupec, A. Drescher, U. Jaehde, M. Gneist, N. Graf v. Keyserlingk, B.K. Keppler and A. Hochhaus
Extended Abstracts
Molecular targets of indirubins
Abstract
S. Jakobs, K.H. Merz, S. Vatter and G. Eisenbrand
Extended Abstracts
KP1019 (FFC14A) from bench to bedside: preclinical and early clinical development ? an overview
Abstract
M.A. Jakupec, V.B. Arion, S. Kapitza, E. Reisner, A. Eichinger, M. Pongratz, B. Marian, N. Graf v. Keyserlingk and B.K. Keppler
Extended Abstracts
Expression profile of copper transporters in sensitive and cisplatin/oxaliplatin-resistant tumor cell lines
Abstract
M.U. Kassack and C. Stratenschulte
Extended Abstracts
Proteomic analysis of chemoresistance to 5-fluorouracil in colon cancer in vitro
Abstract
R.M. Mader, W.M. Schmidt, G. Mitterer and C. Gerner
Extended Abstracts
Flat dose (175 mg/weekly) paclitaxel: pharmacokinetics and clinical implications
Abstract
K. Mross, N. Holl
Extended Abstracts
Enzastaurin and pemetrexed exert synergistic antitumor activity in thyroid cancer cell lines in vitro
Abstract
Enzastaurin and pemetrexed exert synergistic antitumor activity in thyroid cancer cell lines in vitro
Extended Abstracts
Contrast-enhanced MR imaging in the indirect monitoring of drug release from an interstitial depot
Abstract
R.E. Port, C. Schuster, C.R. Port and P. Bachert
Extended Abstracts
Searching for cellular targets of novel pteridines downstream of cAMP PDE inhibition
Abstract
S. Vatter, K.H. Merz and G. Eisenbrand