DOI 10.5414/NP300484

Clinical Neuropathology, Volume 31 - July/August (210 - 215)

A common 8q (MYC) amplification detected in a multifocal anaplastic astrocytoma by SNP array karyotyping

Michelle Madden Felicella1, Jill M. Hagenkord2*, Shera F. Kash2, Martin P. Powers1, Mitchel S. Berger4, Arie Perry1, 4
1 Department of Pathology, University of California San Francisco, San Francisco, CA, 2 Department of Pathology, Creighton Medical Laboratory, Creighton University, Omaha, NE, 3 Department of Laboratory Medicine, 4 Department of Neurosurgery, University of California San Francisco, San Francisco, CA, USA

Abstract

The distinction of multifocal versus multicentric gliomas can conceivably have important therapeutic implications. We present a 27-year-old man with two radiologically distinct non-enhancing infiltrative masses in the anterior frontal lobe and the posterior temporoparietal region. No intervening disease was evident on MRI modalities; the lesions were stable over a period of many months. He underwent two separate resections a few months apart. Given the question of whether his tumors represented two de novo primary multicentric tumors or one multifocal tumor, single nucleotide polymorphism (SNP) array karyotyping and in situ hybridization studies were performed on both tumors. The two tumor profiles looked remarkably similar, histologically and genetically: both were anaplastic astrocytomas with a common 33Mb gain/ amplification of 8q23.3-q24.3, including MYC amplification, suggesting a monoclonal origin. The temporoparietal neoplasm showed several additional genetic alterations. This case illustrates that even with today’s advanced neuroimaging modalities, extensive radiologically invisible tumor may be present between seemingly separate sites of glioma involvement. Thus modern global genomic studies of such tumors may help distinguish whether multiple tumors represent one extensive neoplasm with microscopically invasive disease or multiple genetically distinct tumors.

Author Details

Authors

  • Michelle Madden Felicella1
  • Jill M. Hagenkord2*
  • Shera F. Kash2
  • Martin P. Powers1
  • Mitchel S. Berger4
  • Arie Perry1
  • 4

Departments

  • 1 Department of Pathology, University of California San Francisco, San Francisco, CA,
  • 2 Department of Pathology, Creighton Medical Laboratory, Creighton University, Omaha, NE,
  • 3 Department of Laboratory Medicine,
  • 4 Department of Neurosurgery, University of California San Francisco, San Francisco, CA, USA

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