DOI 10.5414/CNX77S102

Clinical Nephrology, Volume 79 (2013) - Supplement 1 (46 - 48)

High-tone electric muscles stimulation of thigh augments the impaired penile blood flow of diabetic patients without improving symptoms of erectile dysfunction

Miklós Damásdi1*, Katalin Vágási2*, Gergő A. Molnár2, László Farkas1, István Wittmann2
1 Department of Urology, 2  2 nd Department of Internal Medicine, Nephrological Center, University of Pécs, Pécs, Hungary

*Authors contributed equally

Abstract

Objective: Erectile dysfunction (ED) is a major complication in diabetes mellitus. A novel method, high-tone external muscle stimulation (HTEMS), has been proven to be useful in the therapy of diabetic and uremic peripheral polyneuropathy. The aim of this study was to test the potential effect of HTEMS on ED in diabetic patients. Design: An open-label, self-controlled interventional prospective study was conducted at the 2nd Department of Internal Medicine and N.C. University of Pécs, Hungary. Six Type 2 diabetic patients (mean age 59 ± 7 years) with severe ED (International Index of Erectile Function (IIEF) score: 7.7 ± 8.5) and impaired renal function (eGFR: 61 ± 16 ml/min) were involved. Intervention: The thigh muscles of the patients were treated with HTEMS for 1 h 3 times per week for a duration of 4 weeks. Main outcome measures: Penile peak systolic velocity (PSV) (in the flaccid state and semi-rigid (after 10 mg intracavernous papaverine injection)), IIEF score, quality of life and laboratory parameters. At the beginning also the acute effect of HTEMS on penile PSV was investigated. Results: Under basal conditions penile PSV was rather low. The first HTEMS session of the thighs induced an insignificant increase of PSV in the flaccid state (4.1 ± 1.2 to 6.3 ± 3.3 cm/s) and a significant rise of PSV in the semi-rigid penis (from 6.5 ± 2.5 to 8.9 ± 2.2 cm/s (p = 0.009)). After 4 weeks of HTEMS treatment, under basal conditions no significant change of penile PSV (flaccid and semirigid) was observed. Similarly, IIEF score did not improve over the time period (7.7 ± 8.1 vs. 6.7 ± 8.5, p > 0.05). Also, metabolic parameters and eGFR were not influenced. Conclusion: In a pilot study of diabetic patients with severe ED HTEMS of the thighs induced an acute rise of penile PSV in the semi-rigid state. However, after 4 weeks of HTEMS therapy the basal PSV and symptoms of ED were not improved.

Author Details

Authors

  • Miklós Damásdi1*
  • Katalin Vágási2*
  • Gergő A. Molnár2
  • László Farkas1
  • István Wittmann2

Departments

  • 1 Department of Urology,
  • 2 
  • 2 nd Department of Internal Medicine, Nephrological Center, University of Pécs, Pécs, Hungary

    *Authors contributed equally

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