DOI 10.5414/NP300451

Clinical Neuropathology, Volume 31 - May/June (142 - 145)

Identification of t(1;19)(q12;p13) and ploidy changes in an ependymosarcoma: a cytogenetic evaluation

Abeer Z. Tabbarah, Austin W. Carlson, Angelica Oviedo, Rhett P. Ketterling, Fausto J. Rodriguez
1 Department of Pathology, George Washington University, Washington, D.C., 2 Department of Laboratory Medicine, Pathology, Mayo Clinic, Rochester, MN, USA, 3 Children’s, Women’s Health Centre of BC Anatomic Pathology, Vancouver, British Columbia, Canada, 4 Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

Abstract

Gliosarcoma, a recognized subtype of glioblastoma, is a biphasic tumor exhibiting distinct glial and sarcomatous components. Ependymosarcomas are rarer, biphasic ependymal tumors exhibiting sarcomatous change. Genetic abnormalities associated with this curious phenotype are not well understood. We are presenting the first karyotype of ependymosarcoma with identification of a clonal t(1;19)(q12;p13). Fluorescence in situ hybridization (FISH) was performed with a probe set targeting 1q23 and 19p13.3. Although the tumor did not show evidence of t(1;19)(q23;p13.3) by FISH, increased ploidy was a feature of the sarcomatous component. On clinical followup the patient is doing well without evidence of recurrence 55 months after initial resection, and postoperative treatment with irradiation and temozolomide. The significance of the genetic alterations we describe associated with sarcomatoid change in ependymal neoplasms, and ultimately their prognostic relevance, merits further study.

Author Details

Authors

  • Abeer Z. Tabbarah
  • Austin W. Carlson
  • Angelica Oviedo
  • Rhett P. Ketterling
  • Fausto J. Rodriguez

Departments

  • 1 Department of Pathology, George Washington University, Washington, D.C.,
  • 2 Department of Laboratory Medicine, Pathology, Mayo Clinic, Rochester, MN, USA,
  • 3 Children’s, Women’s Health Centre of BC Anatomic Pathology, Vancouver, British Columbia, Canada,
  • 4 Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

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