DOI 10.5414/CN106920

Clinical Nephrology, Volume 76 (2011) - August (136 - 143)

Treatment with cyclosporine A improves SLE disease activity of Japanese patients with diffuse proliferative lupus nephritis

Y. Kamijo1, K. Hashimoto1, K. Takahashi1, T. Ehara2, H. Shigematsu2, M. Higuchi1
1 Department of Nephrology Internal Medicine, 2 Department of Pathology, Shinshu University School of Medicine, Nagano, Japan

Abstract

Aims: Cyclosporine A (CyA), a representative calcineurin inhibitor, may be useful for the treatment of lupus nephritis. In contrast to knowledge about its strong effects against proteinuria, however, there is little information about the beneficial effects of CyA against clinical disease activity of diffuse proliferative lupus nephritis. Methods: To elucidate this issue, we investigated the effects of low-dose CyA treatment (< 2.5 mg/kg/d) in 11 Japanese adult patients (1 male, 10 female) with uncontrolled diffuse proliferative lupus nephritis with severe clinical SLE disease activity. Results: In addition to amelioration of the proteinuric state, the clinical SLE disease activities, estimated by serological markers and the SLE disease activity index (SLEDAI), were significantly improved in all patients within 1 month. The required amounts of corticosteroid were decreased in these patients. These favorable effects continued for 2 y without serious adverse effects. Kidney function was not changed in the patients with satisfactory kidney function prior to CyA therapy (serum creatinine < 1.1 mg/dl, and eGFR > 45 ml/ min/1.73 m2). Conclusion: The current study results suggest that low-dose CyA treatment could ameliorate the severe clinical SLE disease activity as well as improve proteinuria in Japanese patients with diffuse proliferative lupus nephritis. This treatment would be safe and useful for SLE patients with satisfactory kidney function.

Author Details

Authors

  • Y. Kamijo1
  • K. Hashimoto1
  • K. Takahashi1
  • T. Ehara2
  • H. Shigematsu2
  • M. Higuchi1

Departments

  • 1 Department of Nephrology Internal Medicine,
  • 2 Department of Pathology, Shinshu University School of Medicine, Nagano, Japan

Full Text

Add to Cart

Rights / Permissions

This section will be available soon


Shopping Overview
Type Qtty Price
Your basket is empty
View Cart