DOI

Clinical Nephrology, Volume 75 (2011) - Supplement 1 (32 - 36)

Collapsing glomerulopathy in a patient with mixed connective tissue disease

S.I. Rifkin2, H. Gutta2, R. Nair1, C. McFarren2, D.E. Wheeler3
1 Department of Internal Medicine, 2 Division of Nephrology, 3 Departments of Pathology, Cell Biology, Internal Medicine, University of South Florida College of Medicine, Tampa, FL, USA

Abstract

Collapsing glomerulopathy (CG) is a distinct clinicopathological entity characterized by glomerular capillary collapse, podocyte proliferation, diffuse mesangial sclerosis, and podocyte maturation arrest. Initially noted primarily in HIV infected patients, a number of other diseases have now been associated with CG. Mixed connective tissue disease (MCTD) is a disease with overlapping features of systemic lupus erythematosus, progressive systemic sclerosis, and polymyositis. It was originally thought that renal involvement was a rare complication of MCTD. However, over the years, it has become clearer that renal involvement, although not always clinically apparent, is frequent. In this report we present a patient with MCTD who developed CG.

Author Details

Authors

  • S.I. Rifkin2
  • H. Gutta2
  • R. Nair1
  • C. McFarren2
  • D.E. Wheeler3

Departments

  • 1 Department of Internal Medicine,
  • 2 Division of Nephrology,
  • 3 Departments of Pathology, Cell Biology, Internal Medicine, University of South Florida College of Medicine, Tampa, FL, USA

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