Abstract

Collapsing glomerulopathy (CG) is a distinct clinicopathological entity characterized by glomerular capillary collapse, podocyte proliferation, diffuse mesangial sclerosis, and podocyte maturation arrest. Initially noted primarily in HIV infected patients, a number of other diseases have now been associated with CG. Mixed connective tissue disease (MCTD) is a disease with overlapping features of systemic lupus erythematosus, progressive systemic sclerosis, and polymyositis. It was originally thought that renal involvement was a rare complication of MCTD. However, over the years, it has become clearer that renal involvement, although not always clinically apparent, is frequent. In this report we present a patient with MCTD who developed CG.

Author Details

Authors

• S.I. Rifkin²
• H. Gutta²
• R. Nair¹
• C. McFarren²
• D.E. Wheeler³

Departments

• ¹ Department of Internal Medicine,
• ² Division of Nephrology,
• ³ Departments of Pathology, Cell Biology, Internal Medicine, University of South Florida College of Medicine, Tampa, FL, USA

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