DOI 10.5414/CPP47716

Int. Journal of Clinical Pharmacology and Therapeutics, Volume 47 - December (716 - 721)

Juzentaihoto (TJ-48), a traditional Japanese herbal medicine, influences hemoglobin recovery during preoperative autologous blood donation and after hip surgery

Y. Kishida1, T. Nishii2, T. Inoue1, S. Nishida1, J. Arimitsu1, H. Yoshikawa2, N. Sugano2
1 Department of Kampo Medicine, 2 Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan

Abstract

Objective: Preoperative autologous blood donation is a widely used alternative to allogenic transfusion in hip surgery. However, it has been reported that autologous blood donation may induce preoperative anemia. Juzentaihoto (TJ-48) (Tsumura Co., Tokyo, Japan) is a Japanese herbal medicine that has been used to alleviate anemia. We investigated the effect of TJ-48 on anemia in the perioperative period. Patients and methods: 18 hips of 18 female patients who underwent total hip arthroplasty or rotational acetabular osteotomy (RAO) were divided into two groups. Group A consisted of 9 hips of 9 patients who were treated with TJ-48 at a dose of 7.5 g per day from 21 days before surgery to the day before surgery. Group B consisted of 9 hips of 9 patients who did not take TJ-48. Preoperative autologous blood donation was performed 21, 14 and 7 days before surgery. All patients deposited 400 ml each time for a total of 1,200 ml. Hemoglobin level was recorded on preoperative Days 21, 14 and 7 and postoperative Days 1, 4, 7 and 14. Results: During the preoperative period, repeated measures ANOVA showed a significant difference between the two groups in hemoglobin level (p = 0.04). Despite the lack of TJ-48 after surgery, the rate of hemoglobin decline in Group A was less than in Group B at all examination times. No patients with TJ-48 experienced side effects, including gastrointestinal symptoms and unusual laboratory data. Conclusion: TJ-48 is useful for treating anemia during preoperative autologous donation.

Author Details

Authors

  • Y. Kishida1
  • T. Nishii2
  • T. Inoue1
  • S. Nishida1
  • J. Arimitsu1
  • H. Yoshikawa2
  • N. Sugano2

Departments

  • 1 Department of Kampo Medicine,
  • 2 Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan

Full Text

Add to Cart

Rights / Permissions

This section will be available soon


Shopping Overview
Type Qtty Price
Your basket is empty
View Cart