DOI 10.5414/NPP28210

Clinical Neuropathology, Volume 28 - May/June (210 - 212)

Persistent toxoplasma bradyzoite cysts in the brain: incidental finding in an immunocompetent patient without evidence of a toxoplasmosis

L. Pusch1, B. Romeike1, M. Deckert2, C. Mawrin1, 3
1 Department of Neuropathology, Friedrich-Schiller University, Jena, 2 Department of Neuropathology, University of Cologne, Cologne, 3 Institute of Neuropathology, Otto-von-Guericke-University, Magdeburg, Germany

Abstract

We report on a 72-year-old patient in whom autopsy demonstrated incidentally intracerebral Toxoplasma gondii cysts, locally restricted in the occipital lobe, in association with only a few CD4+ and CD8+ T cells and a mild microglial activation. The patient was HIV-negative. Serologically, there was no evidence for an active inflammation (Toxoplasma gondii specific antibody IgG-positive, IgM-negative). This unusual observation may indicate that in patients with sepsis, who may yield to a state of immunodysbalance, a focal reactivation of parasites may ensue in the absence of conditions predisposing for opportunistic infection.

Author Details

Authors

  • L. Pusch1
  • B. Romeike1
  • M. Deckert2
  • C. Mawrin1
  • 3

Departments

  • 1 Department of Neuropathology, Friedrich-Schiller University, Jena,
  • 2 Department of Neuropathology, University of Cologne, Cologne,
  • 3 Institute of Neuropathology, Otto-von-Guericke-University, Magdeburg, Germany

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