ANCA-associated Vasculitis

Further details

G.M Hänsch and K. Andrassy

ANCA-associated Vasculitis

Advances in Pathogenesis and Treatment

edited by G.M. Hänsch and K. Andrassy

2007. X, 75 pages,
10 illustrations (1 four-color), 5 tables
Euro 40.00 / US$ 50.00
ISBN 3-87185-354-8
ISBN13 978-3-87185-354-8

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Autoantibodies to neutrophil cytoplasmic antigens (ANCA) are
associated with numerous chronic inflammatory diseases,
particularly, but not exclusively, with primary vasculitides such
as Wegener's granulomatosis, microscopic polyangiitis, or Churg
Strauss syndrome. To discuss clinic, diagnosis, and therapeutic
options as well as the pathogenesis of ANCA-associated primary
vasculitides, an international conference was established the
so-called "Vasculitis and ANCA-Workshop". In the book,
important contributions from the last Workshop, held in June 2005
in Heidelberg, Germany, are presented.

A role of ANCA in the development and perpetuation of the
disease is presumed – but still controversially discussed
[Hänsch et al.]. Consequently research is focused mainly on the
nature and possible function of the respective autoantigens,
particularly of proteinase 3, the Wegener's autoantigen [Jenne
and Kuhl; Vietinghoff et al.] and the possible role of the autoanti-
bodies in vitro [Little et al.]. As an alternative to the mere function
of autoantibodies, the participation of T-lymphocytes in the
development of vasculitis is a long-term subject of research.
In the paper by Kälsch et al., the seminal findings as well as the
more recent data are summarised, and a concept including
T-lymphocytes in other immunocompetent cells in the develop-
ment of ANCA-associated vasculitis is discussed.

Finally, clinical aspects of ANCA-associated aspects are presented,
including therapy regimens [de Groot and Jayne; Kötter et al.],
as well as insights on the consequences of long-term immuno-
suppressive therapy [Lode and Schmidt-Ioanas].

Contents

Editorial

Membrane proteinase 3 and Wegener’s granulomatosis
S. von Vietinghoff, A. Schreiber, B. Otto, M. Choi, U. Göbel and R. Kettritz

The pathogenesis of ANCA-associated vasculitides: old hypotheses and new insights
G.M. Hänsch, C. Iking-Konert and K. Andrassy

Intravital microscopy in the study of ANCA-associated systemic vasculitis
M.A. Little, C.D. Pusey and S. Nourshargh

The role of T lymphocytes in ANCA associated vasculitis: neglected or revisited?
A.-I. Kälsch, F.J. van der Woude and B.A. Yard

Vasculitis and infection: effects of immunosuppressive therapy
H.M. Lode and M. Schmidt-Ioanas

What is new in the therapy of ANCA- associated vasculitides?Take home messages from the 12th workshop on ANCA and systemic vasculitides
K. de Groot and D. Jayne

Autologous stem cell transplantation of treatment-resistant systemic vasculitis – a single center experience and review of the literature
I. Kötter, T. Daikeler, C. Amberger, A. Tyndall and L. Kanz

Production and applications of recombinant proteinase 3, Wegener’s autoantigen: problems and perspectives
D.E. Jenne and A. Kuhl

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Books in English

Nephrology

ANCA-associated Vasculitis